Clinical research shows that SAM-e elevates mood and has a positive effect on behavior. It also maintains cartilage health and contributes to the production of joint supporting compounds such as Glucosamine and Chondroitin. SAM-e works actively with Folic Acid and Vitamin B12, and together can promote healthy brain functioning. Natural Factors SAM-e is specially coated for ease of swallowing and maximum bioavailability. The coating also enhances SAM-eÂ’s stability. Caution: Individuals who are using prescription anti-depressants or who suffer from bi-polar disorder should not use this product unless under the supervision of a health professional.